After upgrading the VCSA to the latest U2 and also with new machine certificate , noticed vSphere Replication was in failed status and when I tried to configure the lookup service address and restarting the service it was failing with the error BAD EXIT CODE:1.

Noticed in the release notes of the VR it is mentioned as the old IP or certificate of the vCenter will be preserved  in the VR Management Server in its OVF environment which causes the validation of the vCenter Server fails.

As a workaround it is mentioned as to login to the vCenter using web-client and power of and on the vSphere Replication Management Server VM  which forces the update of the OVF environment on the VR Management Server VM which resolves the issue.

Reference:

https://www.vmware.com/support/vsphere-replication/doc/vsphere-replication-60-release-notes.html